Research Articles

Tsvilovskyy V, Ottenheijm R, Kriebs U, Schütz A, Diakopoulos KN, Jha A, Bildl W, Wirth A, Böck J, Jaślan D, Ferro I, Taberner FJ, Kalinina O, Hildebrand S, Wissenbach U, Weissgerber P, Vogt D, Eberhagen C, Mannebach S, Berlin M, Kuryshev V, Schumacher D, Philippaert K, Camacho-Londoño JE, Mathar I, Dieterich C, Klugbauer N, Biel M, Wahl-Schott C, Lipp P, Flockerzi V, Zischka H, Algül H, Lechner SG, Lesina M, Grimm C, Fakler B, Schulte U, Muallem S, Freichel M. OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage. J Clin Invest. DOI: 10.1172/JCI169428
Sliwinski, C; Heutehaus, L; Taberner, Francisco J.; Weiss, L; Kampanis, V; Tolou-Dabbaghian, B; Cheng, X; Motsch, M; Heppenstall, P; Kuner, R; Franz, S; Lechner, S; Weidner, N; Puttagunta, R. Contribution of mechanoreceptors to spinal cord injury–induced mechanical allodynia. PAIN. DOI: 10.1097/j.pain.0000000000003139

Nees TA, Wang N, Adamek P, Zeitzschel N, Verkest C, La Porta C, Schaefer I, Virnich J, Balkaya S, Prato V, Morelli C, Begay V, Lee YJ, Tappe-Theodor A, Lewin GR, Heppenstall PA, Taberner FJ, Lechner SG. Role of TMEM100 in mechanically insensitive nociceptor un-silencing. Nat Comm. DOI: 10.1038/s41467-023-37602-w

Gangadharan V, Zheng H, Taberner FJ, Landry J, Nees TA, Pistolic J, Agarwal N, Männich D, Benes V, Helmstaedter M, Ommer B, Lechner SG, Kuner T, Kuner R. Neuropathic pain caused by miswiring and abnormal end organ targeting. Nature. DOI: 10.1038/s41586-022-04777-z
Verkest C, Schaefer I, Nees TA, Wang N, Jegelka JM, Taberner FJ, Lechner SG. Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2. Nat Comm. DOI: 10.1038/s41467-022-28974-6

Morelli C, Castaldi L, Brown SJ, Streich LL, Websdale A, Taberner FJ, Cerreti B, Barenghi A, Blum KM, Sawitzke J, Frank T, Steffens LK, Doleschall B, Serrao J, Ferrarini D, Lechner SG, Prevedel R, Heppenstall PA. Identification of a population of peripheral sensory neurons that regulates blood pressure. Cell Rep. DOI: 10.1016/j.celrep.2021.109191
Schwaller F, Bégay V, García-García G, Taberner FJ, Moshourab R, McDonald B, Docter T, Kühnemund J, Ojeda-Alonso J, Paricio-Montesinos R, Lechner SG, Poulet JFA, Millan JM, Lewin GR. USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans. Nat Neurosci. DOI: 10.1038/s41593-020-00751-y

Agarwal N, Taberner FJ, Rangel Rojas D, Moroni M, Omberbasic D, Njoo C, Andrieux A, Gupta P, Bali KK, Herpel E, Faghihi F, Fleming T, Dejean A, Lechner SG, Nawroth PP, Lewin GR, Kuner R. SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes. Neuron. DOI: 10.1016/j.neuron.2020.06.037.

Taberner FJ, Prato V, Schaefer I, Schrenk-Siemens K, Heppenstall PA, Lechner SG. Structure-guided examination of the mechanogating mechanism of PIEZO2. Proc Natl Acad Sci U S A. DOI: 10.1073/pnas.1905985116.
Quilis I, Taberner FJ, Martínez-Garay CA, Alepuz P, Igual JC. Karyopherin Msn5 is involved in a novel mechanism controlling the cellular level of cell cycle regulators Cln2 and Swi5. Cell Cycle. DOI: 10.1080/15384101.2019.1578148

Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, Johnsson K, Lechner SG, Heppenstall PA. Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun. DOI: 10.1038/s41467-018-04049-3
Narayanan P, Hütte M, Kudryasheva G, Taberner FJ, Lechner SG, Rehfeldt F, Gomez-Varela D, Schmidt M. Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons. Elife. 2018. DOI: 10.7554/eLife.32346
Schaefer I, Prato V, Arcourt A, Taberner FJ, Lechner SG. Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors. Mol Pain. DOI: 10.1177/1744806918814640

Prato V, Taberner FJ, Hockley JRF, Callejo G, Arcourt A, Tazir B, Hammer L, Schad P, Heppenstall PA, Smith ES, Lechner SG. Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors. Cell Rep. 2017. DOI: 10.1016/j.celrep.2017.11.066
Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA, Lechner SG. Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination. Neuron. DOI: 10.1016/j.neuron.2016.11.027.

Taberner FJ^Y, Devesa I, Ferrer-Montiel A. Calcium Entry Through Thermosensory Channels. Adv Exp Med Biol. Y Corresponding author. DOI: 10.1007/978-3-319-26974-0_12

Caires R, Luis E, Taberner FJ, Fernandez-Ballester G, Ferrer-Montiel A, Balazs EA, Gomis A, Belmonte C, de la Peña E. Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain. Nat Commun. DOI: 10.1038/ncomms9095
Taberner FJ, Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A. TRP channels interaction with lipids and its implications in disease. Biochim Biophys Acta- BIOMEMBRANES. DOI: 10.1016/j.bbamem.2015.03.022

Taberner FJ, López-Córdoba A, Fernández-Ballester G, Korchev Y, Ferrer-Montiel A. The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation. J Biol Chem. DOI: 10.1074/jbc.M114.577478.

Aguado-Llera D, Bacarizo J, Gregorio-Teruel L, Taberner FJ, Cámara-Artigas A, Neira JL. Biophysical characterization of the isolated C-terminal region of the transient receptor potential vanilloid 1. FEBS Lett. DOI: 10.1016/j.febslet.2012.03.030.
Taberner FJ, Quilis I, Sendra J, Bañó MC, Igual JC. Regulation of cell cycle transcription factor Swi5 by karyopherin Msn5. Biochim Biophys Acta. DOI: 10.1016/j.bbamcr.2012.02.009.

Taberner FJ, Quilis I, Igual JC. Spatial regulation of the start repressor Whi5. Cell Cycle. DOI: 10.4161/cc.8.18.9621

Lukovic D, Plasencia I, Taberner FJ, Salgado J, Calvete JJ, Pérez-Gil J, Mingarro I. Production and characterisation of recombinant forms of human pulmonary surfactant protein C (SP-C): Structure and surface activity. Biochim Biophys Acta. 2006 Apr;1758(4):509-18. doi: 10.1016/j.bbamem.2006.03.005.